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A., Nicora, R., Ashbrook, D., and Kopple, J
A GLP-1R agonist (liraglutide) increased endothelial nitric oxide synthase phosphorylation and nitric oxide (NO) production by the 5-AMP-activated protein kinase (AMPK)-dependent pathway and subsequent NO production in cultured HCAEC [56],[57]
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The powder may have degraded before reconstitution due to improper storage, high temperature exposure, or moisture infiltration into the sealed vial
For example, the LEADER trial showed positive renal effects with the use of liraglutide primarily by the reduction of macroalbuminuria
By subcutaneous injection
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