Exendin-4 and exenatide are both GLP-1 receptor agonists
Astrocyte-specific genes (e.g., Gfap, Aqp4, Mat2a, Mafg , and DNMT3B ) have unique DNA methylation profiles that stabilize astrocyte identity upon the inflammation (Wheeler et al., 2020)
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In clinical trials, participants taking the highest dose of orforglipron lost up to 15% of their body weight by week 72
Injection Therapy Recovery Most can resume their regular activities right after treatment, with no downtime required