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The rapid uptake of GLP-1RAs in rheumatology has raised an urgent mechanistic question: are clinical gains in PsA driven purely by weight reduction, or do these agents carry intrinsic anti-inflammatory properties

Neuropharmacology 130:4253

Now being studied seriously

At the highest dose (12 mg weekly), mean body weight reduction reached 24.2%, compared with a 2.1% reduction in the placebo arm

CJC-1295 is a long-acting analogue of growth hormone-releasing hormone (GHRH) that induces prolonged stimulation of growth hormone (GH) 1 and increased insulin-like growth factor-1 (IGF-1) secretion in humans