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After that it clears your system and your body takes over and begins producing its own growth hormone for the next 24 hours
For example, the STEP 1 trial of once-weekly semaglutide (2.4 mg) in people without diabetes achieved a ~15% average body weight reduction over 68 weeks (source), with a mean baseline BMI of ~38 (source)
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When you eat, GLP-1 is naturally released from your gut these medications mimic that hormone at sustained, higher concentrations
However, 15 to 30% gained weight
doi: 10.2174/0109298673251025230919105818
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