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The combination of smaller sizes and altered orbital energies affect coordination preferences
Acute administration of a Y1-R agonist may also reduce the rate of insulin secretion by pancreatic -cells 3,22
2 Challenges of developing an oral peptide therapy The oral administration of peptides is not a new concept, and the challenges faced are best illustrated by considering the failure to date to produce a marketable oral formulation of insulin since its discovery in 1921 [1, 2, 8, 40]
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These drugs combine weak opioid effects with norepinephrine reuptake inhibition
