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Clinical use of oral semaglutide indicated its ability to decrease systolic and diastolic blood pressure and improve lipid profiles by reducing triglycerides and LDL-cholesterol levels

The HR for non-fatal MI was 1.18 (95% CI 0.73, 1.90) and for non-fatal stroke was 0.74 (95% CI 0.35, 1.57)

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However, the SOUL trial reported broadly consistent treatment effects for the primary MACE outcome across prespecified subgroups, including CKD-only, CAD-only, and combined CKD/CVD groups (Fig