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La tasa de discontinuacin por eventos adversos en ensayos clnicos rara vez excede el 5-8%, y la inmensa mayora de efectos reportados son leves, transitorios y manejables mediante titulacin o ajuste de timing

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Western blotting showed that TGF-1 + IL-1 treatment time-dependently upregulated the expression of NLRP3, ASC and active caspase-1 p20 in fibroblasts, while GSDMD-NT did not change significantly (Fig

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