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They enhance cardiac function, combat heart failure, facilitate myocardial energy uptake, reduce inflammation, alleviate oxidative stress, and inhibit myocardial structural remodeling
The shares of adults who report ever taking these drugs is highest among people with diabetes (43%), followed by those with heart disease (26%) and those who are obese or overweight (22%)
STEP 2 focused on adults with type 2 diabetes and showed a mean weight loss of approximately 9.6%, lower than STEP 1 but still clinically meaningful given the metabolic complexity of diabetes
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For people comparing these medications, the practical takeaway is that Retatrutide may offer a more aggressive approach to fat reduction, while Zepbound provides a well-established and effective dual pathway
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