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While little is known about the role of this GLP-1R population, a function of the Brunner's glands is to secrete mucus to lubricate the intestinal wall and, as GLP-1 has been suggested to be a positive regulator of gut-barrier function, GLP-1 may act on these glands to increase mucus secretion, thereby decreasing inflammation and protecting against intestinal damage

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If prescribed, domperidone should only be used at the lowest effective dose for up to 7 days due to cardiac risks (QT prolongation), and is contraindicated in patients with certain cardiac conditions or taking interacting medications