After the initial weight loss period, patients were split into two groups: Group 1 Continued tirzepatide: Lost an additional 5.5% of body weight over the next 52 weeks Group 2 Switched to placebo (stopped tirzepatide): Regained 14% of their body weight over the next 52 weeks A follow-up analysis published in JAMA Internal Medicine in November 2025 added an important detail: 82.5% of participants who stopped tirzepatide regained at least 25% of their lost weight within one year
Zhuang J, Rao F, Wu D, Huang Y, Xu H, Gao W, Zhang J, Sun J
You can also view Ozempics prescribing information or talk with your doctor
Even so, if you have Ozempic sulfur burps or diarrhea, discussing alternative GLP-1 agonists with your healthcare provider may be worthwhile, as research shows that the side effect profile can vary between different GLP-1 medications
"There is no evidence that these drugs are effective at that small amount," said Apovian, who has received grants from Novo Nordisk
Reduced immunity