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Importantly, this tolerance window doesn't mean the medication stops workingappetite suppression and weight loss benefits actually improve during weeks two through twelve as your body adjusts

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doi: 10.3389/fcell.2025.1718220 Received 03 October 2025 Revised 26 October 2025 Accepted 27 October 2025 Published 13 November 2025 Volume 13 - 2025 Edited by Qiong Lu, Central South University, China Reviewed by Yangyang Zhang, Shanghai Jiao Tong University, China Updates Copyright 2025 Wu, Li, Ju, Zeng and Cao