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drug effect requires functioning beta cells (Type 1 diabetics have few functioning beta cells, and beta cells numbers can also decline over time in type 2 diabetes) Indications: type II diabetes a drug of choice for patients where metformin is contraindicated (or who cannot tolerate metformin) can be added in combination with other hypoglycemic drugs or insulin Contraindications: type I diabetes (where patients lack pancreatic -cells) Use with caution in patients with significant hepatic impairment (due to a high risk for hypoglycemia)