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Why this matters: injectable GLP-1s like semaglutide and tirzepatide achieve 15 to 20% weight reductions, but injections, cost, and adherence limit real-world use (Santulli review, Journal of Diabetes & Metabolic Disorders, 2025)
Continued loss may still happen, but the conversation often includes maintenance, muscle preservation, and long-term habits
And while it may sound obvious, wearing layers and increasing the room temperature can also do the trick
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All analyses were conducted using R software (version 4.2.3)
During moderate calorie restriction, IGF-1 levels temporarily increased, aiding fat loss while preserving lean tissue
