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The ORF2 reading frame does not contain an AUG translation initiation codon and as such translation through ORF2 requires the failure of the ribosome to terminate at the end of ORF1 and instead shift to the +1 reading frame
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[PMID: 35370999] PubMed record related to this compound for laboratory literature review
Goldstein AL, et al
Singh AK, Rai SN, Maurya A, Mishra G, Awasthi R, Shakya A, Chellappan DK, Dua K, Vamanu E, Chaudhary SK, Singh MP (2021) Therapeutic potential of phytoconstituents in management of Alzheimers disease
Based on these trends, they might suggest slowing the taper, pausing dose reductions, or making dietary tweaks
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