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The Phase 2 trials showed that participants losing under 5% by week 12 were rare, accounting for only 8% of the cohort, and that most of them eventually caught up through the next titration phase

Jiang Y, Xu Y, Zheng C, et al

What matters is having an exit plan we taper deliberately and support the transition, so the weight you lost stays lost

In 2017, a small single-center randomized trial of 62 participants, but with longer follow-up, found benefit with exenatide given once weekly (see graph below)

Though it might not be as fast-acting or effective as tretinoin, it provides similar benefits without the intensity or higher risk of ittiration

Evidence has shown a relationship between autophagy and oocyte development and survival