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Shaking generates shear stress and an air-liquid interface that promote peptide aggregation, and the resulting foam traps material out of solution

of Taylor (6), and most recently, in COVID-19 (7, 8)

Vicari, E

Treatment typically begins with a low starter dose (0.25 mg weekly for 4 weeks), followed by gradual increases (0.5 mg, then up to 12 mg weekly for Ozempic, or up to 2.4 mg for Wegovy), depending on tolerability and clinical response

PMID: 26438184

They are used, when appropriate, within a broader GLP-1 Weight Loss for Longevity framework that emphasizes body composition, metabolic health, protein adequacy, resistance training, cardiovascular risk reduction, and long-term maintenance