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Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible

Additionally, CoQ10 itself acts as a potent lipid-soluble antioxidant, providing a second layer of defense against lipid peroxidation within the mitochondrial membrane