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Whilst GLP-1 receptors are abundant in the pancreas and gastrointestinal tract, they are also present in various brain regions, including areas involved in mood regulation and emotional processing
Individuals with gastrointestinal disorders like celiac disease, Crohn's disease, or surgical alterations in the gastrointestinal tract may also experience impaired B12 absorption
The drugs are not equally safe, effective or tolerable for all patients (Ghusn, et al, 2024), and large-scale prescribing without understanding likely response can lead to unsustainable budget pressures that crowd out other essential health services
Women also experience nausea at higher rates
In retatrutide's phase 2 trial, nausea occurred in 47% of participants on the 12 mg dose and vomiting in 25% [2]
Patients had the same ideas with pens and vials
