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102 A placebo-controlled trial that included 54 overweight men with vitamin D deficiency participating in a weight loss program found 3,332 IU (83.3 mcg) of vitamin D daily for one year increased total testosterone (from 10.7 to 13.4 nmol/L [309 to 386 ng/dL]), bioavailable testosterone (from 5.21 to 6.25 nmol/L [150 to 180 ng/dL]), and free testosterone levels (from 0.222 to 0.267 nmol/L [6.4 to 7.7 ng/dL]), whereas placebo led to no significant changes in testosterone levels

The format arose in the research-chemical market, where combining separately sold materials into one listing is an ordinary commercial move, and it propagated between vendors the way conventions in that market usually do, by imitation rather than by evidence

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