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When gain-of-function LRRK2 mutants are anchored to mitochondria, it phosphorylates and traps Rab10 nearby (Gomez et al., 2019), causing decreased interaction of Rab10 with OPTN (optineurin), which is an autophagy receptor, therefore impairing mitophagy (Wauters et al., 2020)

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Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

GHK-Cu, or copper tripeptide-1, is a small, skin-permeable peptide consisting of glycine, histidine, and lysine bound to copper

In vitro (made in the lab not on real people) and animal studies have shown that it may produce hormonal (estrogen-like) effects

Researchers should apply a consistent standard when sourcing this compound for laboratory use