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In vivo , co-administration of polystyrene nanoplastics and the A53T mutant promoted synergistic gut-to-brain transmission in mice, resulting in progressive impairment of physical and motor functions resembling typical Parkinsonian symptoms

It causes painful swelling, heaviness, sensitivity, and a frustrating resistance to diet and exercise

GSH prevented these developments by blocking the ROS/TGF/SMAD signalling pathway (Fig

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In the last 25 years, several studies have tried to assess whether this could be replaced by oral supplementation