However, a BMI in the obese range has been associated with low-grade inflammation, which could cause worse outcomes
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It has not been quantified
Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, et al
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Patients should also seek advice if they experience inadequate weight loss (less than 5% body weight after 6 months on the maintenance dose) as NICE guidance and the SmPC indicate treatment should be reviewed