May 24 2018;5(5):Cd010287
Small shift
While it is primarily used to treat growth hormone deficiency, some adults may benefit from Sermorelin if they have clinically low growth hormone levels, which can affect metabolism, energy, and body composition
The fusion product is resistant to DPP-4 degradation, due to an alanine to glycine substitution at position 2 (A2G) in each of the peptide sequences 28,29 , and has a plasma half-life of five days on average in humans 30,31,32
In research contexts, it is studied as a discrete pentadecapeptide with reproducible physicochemical properties, allowing its use in biochemical, cellular, and preclinical experimental systems
The Food and Drug Administration (FDA) may no longer approve the drug based on new safety evidence