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It suggests an additive anti-inflammatory effect beyond what standard RA medications achieve
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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy
Electronic supplementary material The online version of this article (doi:10.1186/1550-2783-4-22) contains supplementary material, which is available to authorized users
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