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Cell viability and proliferation assessment Mouse macrophages and HFDPCs were seeded in a 96-well plate at a density of 5 10 4 cells/well and cultured until approximately 80% confluence
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(4) insulin resistance in adipocytes (increased lipolysis)
Protocol details: Cerebrolysin: 10 ml IV, 5 days per week for 4 weeks Donepezil: 10 mg daily (or current prescribed dose) Assessment: ADAS-cog and CIBIC+ at baseline, week 4, and week 12 Repeat: Cerebrolysin courses every 3 months while maintaining daily donepezil The clinical trial supporting this combination found that the dual approach produced the best cognitive scores at every study visit compared to either monotherapy
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