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This builds on his work to understand 'how circulating GLP-1 can produce multiple actions, both directly and indirectly, on multiple organs' which he has pursued for many years with colleagues (McLean, Wong, Campbell)
Like many other researchers at the time Tschp thought leptin might be a promising candidate for treating obesity
However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10
The value of long-term albumin administration was investigated in the ANSWER study, a multicenter, randomized, open-label trial that assigned 440 patients with cirrhosis and uncomplicated ascites resistant to diuretic therapy to receive either standard medical therapy or standard medical therapy plus albumin (40 g twice weekly for 2 weeks, and then 40 g weekly) for up to 18 months
Dennoch bleibt das konkrete Milligramm-Verhaeltnis eine Extrapolation
