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Polymeric delivery systems for nucleic acid therapeutics: approaching the clinic
Cysteine Supplies the reactive thiol group central to antioxidant activity Glutamic acid Structural amino acid in the tripeptide Glycine Completes the tripeptide structure Understand the science
Half-life is relatively dose-independent for both peptides clearance pathways (renal filtration, enzymatic degradation, receptor-mediated endocytosis) operate at fixed rates regardless of dose within the therapeutic range
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10.1016/S0140-6736(18)32261-X 10
24, 14 Dec
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