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Most side effects are mild and tend to resolve within the first few weeks
Philp et al
However, it is important to note that these two interventions do not replace the need for a healthy lifestyle
Bioorg Chem 2021;106:104492.ArticlePubMed 128
In the SURMOUNT-4 trial, participants who stopped tirzepatide after 36 weeks regained an average of around 14% of their body weight within the following year, although at 88 weeks the group that stopped had still maintained around 10% of their original weight loss overall
these receptors have also been implicated in positively regulating gut-barrier function and inflammation (98)
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