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Thus, the longer survival of patients with higher IGF-1 levels could be related to direct biological actions of IGF-1, to an overactivation of a protective GH-IGF-1 pathway or to altered IGF-1 levels in patients with a favorable metabolic status

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PubMed Central , Journal of Psychiatric Research , vol

These modifications result in a longer half-life (approximately 2030 hours) and reduced binding to IGF-binding proteins, making it about three times more potent than native IGF-1

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