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2025 Apr;242(4):717-724

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SAFETY SIGNALS Twenty-eight-day intramuscular dosing in rats and dogs produced what FDA called clinically relevant safety signals: altered activated partial thromboplastin time and liver-associated changes (ALT, glucose, triglycerides)

Unlike most peptides that originate from nuclear DNA, MOTS-c is encoded within the mitochondria, offering unique metabolic effects at the cellular energy level