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Keatings VM, Barnes PJ

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Study has proven that TGF- signaling in retinal endothelial cells is amplified in early DR, promoting collagen cross-linking and basement membrane rigidity ( 2.1.2 Pericyte apoptosis Pericyte apoptosis is universally recognized as the earliest functionally significant and morphologically identifiable lesion in diabetic retinopathy, occurring months to years before microaneurysms become visible clinically

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