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Only central lines of the wells in the plates where used for culture

In particular, it influences cell proliferation and renewal

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Published research has explored its role in promoting angiogenesis (new blood vessel formation), upregulating VEGF (vascular endothelial growth factor), stimulating fibroblast migration and collagen deposition, modulating nitric oxide pathways, and protecting the gastrointestinal lining

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Here, we could demonstrate that blocking zonulin with the specific antagonist larazotide acetate was sufficient to restore the impaired barrier function in intestinal organoid cultures exposed to complete fecal supernatants from CIA mice containing high zonulin levels