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In differentiated C2C12 skeletal muscle cells, TRPV1 mediated Ca 2+ entry activates CaMKK2 and AMPK, enhancing glucose oxidation and ATP production through insulin independent mechanisms

That language applies with equal force to downstream IGF-1 analogues whose primary appeal is the same performance context

Extension of the native insulin-like growth factor-1 sequence by 13 amino acids and substitution of glutamic acid-3 with arginine produced a structurally distinct analogue central to IGF-1 receptor signalling studies

Norris, A

The D-Ala substitution provides dual benefits: modest intrinsic potency enhancement (3-fold in vitro) plus substantial protection against dipeptidylpeptidase IV (DPP-IV) degradation, which normally cleaves between positions 2 and 3

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