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On three visits (before, 3 months in, and after 6 months of supplementation), subjects exercised for 30 min on a low intensity (50% Wmax), 30 min on a higher intensity (80% Wmax), and finally performed a 30 min all-out time trial test

Melanotan I (also known as afamelanotide) acts on MC1R and has increased resistance to enzymatic breakdown, whereas melanotan II is a shorter cyclic variant that increases pigmentation at a lower cumulative dose and is less specific and more lipophilic, thereby crossing the blood-brain barrier more easily, leading to more widespread adverse effects

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References Townsend DM, Tew KD, Tapiero H

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