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however, the number of c-fos- positive cells in the liraglutide treated group (CM + Lira, 51 11.22) was significantly decreased compared with that in the CM group (72.67 10.69) (Fig

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These results were well predicted by the plasma stability of the hybrids as all the compounds ( 2 , 5 and 9 ) with similar plasma stability to peptide 1 gave comparable results in vivo

Comparative receptor pharmacology: evaluation of triple-agonist profiles against dual- and single-receptor agonists for differences in receptor-binding kinetics and downstream biological responses

10.1016/j.cmet.2006.01.004 15