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Barroso, M

It is your provider adjusting the protocol to your individual response

Many abnormal molecular pathways are involved in these pathophysiological changes, including the abnormal activation of Sirtuin1, Klotho, fibroblast growth factor 21 (FGF21), the renin-angiotensin-aldosterone system (RAAS), Insulin-like Growth Factor Binding Protein (IGFBP), NRF2, and mTOR [120,121]

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Patients who titrate slowly and avoid large, heavy meals during these periods typically manage far better than those who rush the escalation