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However, RAS inhibition has not yet been found to prevent kidney disease among those with type 1 diabetes, normal blood pressure and without albuminuria, and also does not prevent the progression of histological changes associated with DKD at the early stage of disease [22]
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Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP (Haas et al., 2007)
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