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Tirzepatide led to a percent reduction in fat mass approximately three times greater than the reduction in lean mass

Observation time is curtailed at a maximum of 109 weeks to align with the analysis timeframe

Alcohol - Although citalopram did not potentiate the cognitive and motor effects of alcohol in a clinical trial, as with other psychotropic medications, the use of alcohol by depressed patients taking citalopram is not recommended

The icodec study product strength was 700 U/mL (equivalent to 4200 nmol/mL) (Novo Nordisk) and the semaglutide study product strength was 1 mg/mL (equivalent to 243 nmol/mL) (Novo Nordisk)

Fasting Required: No

The SURMOUNT-1 trial found that participants on tirzepatide 15mg achieved an average weight loss of 20.9% of body weight, while the STEP 1 trial found semaglutide 2.4mg produced an average of 14.9%