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This therapeutic effect was mechanistically linked to reductions in pro-inflammatory cytokines (TNF-, IL-1), enhancement of antioxidant defenses (e.g., increased superoxide dismutase activity), suppression of apoptosis via caspase-3 inhibition, and modulation of NF-B pathwayscollectively yielding neuroprotection and symptomatic relief ( Curcumin shows therapeutic potential for managing peripheral neuropathic pain through multiple mechanisms (Hasriadi et al., 2021)
Carrasco-Zanini, J
A.MendesI
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ACSL4, acyl-CoA synthetase long-chain family 4
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