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Considering that growing and proliferating GSCs generate a force that pushes on the DTC, something necessary for DTC migration during development 25 , that force must be squeezing the DTC against the gonad arms distal basement membrane

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In patients with irritable bowel syndrome, supplementation reduced related symptoms (36)

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Moving forward, understanding proteostasis at a systems level, as an interactome rather than a pathway, will be essential for decoding disease mechanisms and designing truly effective therapeutic interventions

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