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But medications leading to so much weight loss may be needed for people with severe obesity (a BMI of 35 or more) or the 10% of patients who dont respond to GLP-1 medications and need something more powerful, Azar said

Petronini PG, Urbani S, Alfieri R, Borghetti AF, Guidotti GG

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Additionally, it has been shown to reduce the risk of major cardiovascular events such as heart attack, stroke or death in adults with type 2 diabetes mellitus and established cardiovascular disease

Normal-BMI Indians using GLP-1 for cosmetic weight loss Urban Indians with a BMI of 21 to 22 kg/m who take GLP-1s purely to look thinner often tolerate side effects poorly because they have limited metabolic and nutritional reserve