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Unlike classic GLP-1 receptor agonists, tirzepatide acts on two receptors at the same time, namely GIP and GLP-1
10.1016/j.bcp.2024.116471 44 LeeY
7 Untreated, MASH can lead to fibrosis, cirrhosis, and, potentially, hepatocellular carcinoma
Proton pump inhibitors (PPIs): PPIs, like omeprazole and lansoprazole, are stronger acid reducers that are often prescribed for people with chronic gastritis or severe acid reflux
Appetite suppression typically becomes more consistent as the dose increases, with stronger and more stable effects developing over 48 weeks
According to Truveta Research presented at ISPOR 2025, side effects were the leading reason patients stopped taking GLP-1 medications, accounting for 28.2% of all discontinuations
