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Stay at the current dose for an additional one to two weeks before increasing

Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6

It was originally developed for type 2 diabetes management (Ozempic) but showed such dramatic weight loss effects that the FDA approved a higher-dose formulation for chronic weight management (Wegovy)

FDA Approves New Medication for Chronic Weight Management (Zepbound)

Acta 1805, 123140

doi: 10.1038/s41419-023-05645-y