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The vertex (crown) often shows different permeability than the frontal hairline, which may explain why some areas respond differently to topical treatments

Translational andrology and urology , 9 (Suppl 2), S149S159

While this has not been observed in humans at standard doses, and microdoses are far below standard doses, patients with existing thyroid conditions (including Hashimoto) should have regular thyroid monitoring

We also suggest avoiding heavy alcohol consumption immediately after your visit, as alcohol can stress the liver and interfere with how your body processes the new nutrients

Mao T et al

OTC Option: Combine an osmotic (Miralax) to hydrate the system, plus a stool softener (Colace) to make it comfortable to pass