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L2-Cmu development and validation To target IGF-1R action in mice, we utilized the mAb, L2-Cmu (Amgen Inc, Thousand Oaks, CA), which is a murinized IgG1 version of the fully human L2-C mAb previously reported by Calzone et al

Looking at adverse events of special interest, these were low and did not appear to be different between semaglutide and tirzepatide (Table 2)

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Microdosing Split dosing protocols for improved tolerability

Alongside about 10% weight loss over 18 months, the proportion of men with normal levels of both total and free testosterone climbed from 53% to 77% [2]