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The cardiovascular data is sobering and deserves serious consideration
The key is that GLP-1 RA medications are long-lasting receptor agonists that have an effect lasting much longer than naturally produced GLP-1
CJC-1295 (when with DAC) appears to possess a longer half-life of about 6-8 days, which would mean a sustained increase in growth hormone levels
It has also been reported that exenatide and liraglutide induced an increased concentration of ANP through the GLP-1 receptor-dependent pathway (108)
So far, clinical trials have not demonstrated a consistent rise in atrial fibrillation events related to this modest chronotropic change
A variant in MC4R , central to satiety and energy balance, works alongside GLP1R the target receptor plus FTO and TCF7L2 in fat mass and glucose regulation
