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Rather than acting solely through weight loss or peripheral glucose control, GLP-1 therapies engage neural pathways involved in energy regulation, inflammation, synaptic integrity, and protein homeostasisoffering a biologically coherent explanation for their emerging association with preserved cognitive function and reduced dementia risk
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The most important effect of a GLP-1 analog is the ability to stimulate glucose-dependent insulin secretion in -cells
Fletcher JM, Morton CJ, Zwar RA, Murray SS, OLeary PD, Hughes RA (2008) Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor
She was deeply worried that the boy's moles might be early melanomas
But for some people, the nausea was severe enough that they dropped out of the trial entirely
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