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Each individuals set of triggers may also change over time, depending on his or her life situation
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Cryogenic electron microscopy studies suggest that human Hs HOP binds to all components of the HSP70HSP90GR complex via the TPR2A, TPR2B and C-terminal domains, but the TPR1 domain is not involved in complex formation or GR activation 26,37
Slow titration schedules, typically adding one dose increment every four weeks, appear to reduce dropout rates due to gastrointestinal side effects
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More serious but rare complications can include pancreatitis (seek urgent medical attention for severe, persistent abdominal pain with or without vomiting), gallbladder disease (symptoms include upper abdominal pain, fever, jaundice), and diabetic retinopathy complications
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