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Limited long-term human safety data

Since antipsychotics are often chronically prescribed beginning in childhood, cardiometabolic risk accumulates

Collagenase clostridium histolyticum for the treatment of Dupuytrens contracture: systematic review and economic evaluation

When the soft center of a spinal disc pushes through its outer ring, it can press directly on the sciatic nerve

In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)

Some experience this at starting doses, she notes, adding that she has many patients who have lost significant weight without ever escalating the dose