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Target(s) : Dipeptidyl Peptidase-4 Mechanism of Action : Inhibits the enzyme DPP-4, resulting in increased activity of incretins (e.g., GLP-1)
Metformin reduces intestinal absorption of Vit B12 in up to 30% of patients, and dose-dependently lowers serum Vit B12 level in 5-10% of patients (Aroda et al, 2016
Reduced caloric intake can temporarily affect mood, energy, and mental clarity
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Currently, behavioral change is not guaranteedif weight returns after stopping the drug, long-term outcomes suffer